P21 (Nootropic) (P021)

Standard manufacturer protocol: 5 clicks morning + 5 clicks evening (total 10 clicks = 500 mcg/day, 1 click = 50 mcg). Set pen programmer to "5" (1 division = 1 click). Subcutaneous injection in abdomen or anterior thigh. After injection wait 10 seconds before withdrawing needle. Rotate injection sites to avoid induration.

1 pen 10 mg (200 clicks) — for ~20 days = complete course. Break between courses 2–4 weeks. Optimally 2–3 courses per year.

Storage: 2–8°C in refrigerator. MSSPT technology makes formula tolerant to brief temperature deviations above 8°C during delivery.

Combines well with Nootropics Booster (ac-semax-nh2) for synergistic memory and concentration effects, or with AC-Selank-NH2 — for stress, mood and cognitive function impact.

Before starting — DOZA specialist consultation to select scheme for your needs.

P21 (P021) — synthetic neurogenic peptide developed through "reverse engineering" of Cerebrolysin. Scientists isolated the active fragment of ciliary neurotrophic factor (CNTF) responsible for Cerebrolysin's neuroprotective and neurogenic effects, combining it with an adamantane base. Adamantane provides enhanced blood-brain barrier penetration and protects the molecule from enzymatic degradation — making P21 one of the few peptides effective via subcutaneous administration.

In studies, P21 has shown potential in stimulating neurogenesis (formation of new neurons in the hippocampus — memory zone), improving short-term and long-term memory, enhancing concentration and attention, providing neuroprotection from oxidative stress and Aβ/tau protein accumulation (potential for Alzheimer's disease), increasing stress resilience and mood support. Works through LIF (leukemia inhibitory factor) inhibition and BDNF elevation.

DOZA supplies P21 in pre-mixed pen format by Pen Peptide: 10 mg (200 clicks, 1 click = 50 mcg) in stabilized MSSPT (Molecular Structure Stabilization Process Technology) form. Purity ≥98%, synthesis in certified GMP laboratories, 2–8°C storage with cold chain delivery to your door. 1 pen = 1 complete course ~20 days. Combines well with Nootropics Booster (ac-semax-nh2) and AC-Selank-NH2.

P21 (P021) — synthetic neurogenic peptide created through "reverse engineering" of Cerebrolysin. Represents a modified CNTF (ciliary neurotrophic factor) fragment with adamantane base for blood-brain barrier penetration. Primary mechanism: LIF (leukemia inhibitory factor) inhibition — factor that blocks neurogenesis in adult brain, with simultaneous BDNF expression increase through STAT3 signaling pathway (Bolognin et al., J Alzheimers Dis 2014: +35-50% new neurons in hippocampal dentate gyrus). Additional effects: reduced β-amyloid and hyperphosphorylated tau protein accumulation (Alzheimer's potential — Kazim & Bhatt, Neurobiol Aging 2017), improved LTP (long-term potentiation) — cellular basis of memory formation, neuroprotection from oxidative stress. Adamantane base ensures enzymatic stability and effective subcutaneous administration (unlike Cerebrolysin requiring intravenous administration). DOZA supplies P21 in Pen Peptide injection pen format (10 mg, 200 clicks) — precise dosing, higher bioavailability compared to intranasal administration.