NMN (НМН)

Standard anti-aging protocol:

• Initial dose: 250 mg/day in the morning on empty stomach or with a small amount of food (reduces possible nausea).

• After 7 days — increase to 500 mg/day (one dose in the morning).

• Duration: 2-3+ months for cumulative effect, or 30 days × 2-3 courses/year with 1-2 week breaks.

Synergy with resveratrol:

Many protocols include adding resveratrol 100-500 mg/day — it activates SIRT1, increasing NMN→NAD+ efficiency. Take together, preferably with fat (omega-3 or nuts) for better resveratrol absorption.

Storage: in a dry cool place, no refrigeration needed. Avoid direct sunlight and moisture.

Not intended for injection — this is an orally active form.

For rapid effect and higher tissue NAD+ — choose subcutaneous injectable NAD+.

Before starting — consultation with DOZA specialist.

NMN (nicotinamide mononucleotide) — direct precursor of NAD+ (nicotinamide adenine dinucleotide), a key coenzyme for cellular energy and longevity. Unlike NAD+, which is injected subcutaneously, NMN is well absorbed in capsule form through the specialized Slc12a8 transporter in the intestine and is directly converted to NAD+ via the enzyme NMNAT (nicotinamide nucleotide adenylyltransferase).

NMN is actively studied at David Sinclair's Harvard laboratory as one of the most promising anti-aging agents. The key advantage of NMN is its convenient oral format for long-term daily use, unlike NAD+ injections. In clinical studies, NMN increased blood NAD+ levels by 40-50%, improved endurance, insulin sensitivity, and cognitive functions in middle-aged and older adults.

NMN supports cellular rejuvenation, energy metabolism, sirtuin activity (longevity genes), and protection against age-related changes. Particularly popular among biohackers, athletes, and people over 35-40 years old for maintaining energy levels, sleep quality, physical fitness, and cognitive clarity. In the context of GLP-1 weight loss programs, NMN is a component of long-term maintenance anti-aging strategy.

Note: NMN is an orally active supplement (capsules), not an injectable preparation in Pen Peptide format. For rapid effect and injection format — choose NAD+. For long-term daily use in a comfortable format — NMN.

NMN — direct NAD+ precursor: the NMN molecule is absorbed through the specific Slc12a8 transporter in the small intestine (Grozio et al., Nature Metabolism 2019) and converted to NAD+ inside cells via the enzyme NMNAT (nicotinamide nucleotide adenylyltransferase). Increased NAD+ activates: sirtuins (SIRT1–SIRT7) — deacetylases of "longevity genes", mitochondrial biogenesis and stress response; PARP-1 — DNA repair enzyme; CD38 — immune signaling. In clinical studies, NMN increased blood NAD+ by 40-50% over 8-12 weeks at doses of 250-500 mg/day (Yi et al., GeroScience 2023). David Sinclair's protocol (Harvard): 1000 mg NMN + resveratrol each morning — one of the world's most famous anti-aging protocols (Sinclair, Lifespan: Why We Age, 2019). Unlike NR (nicotinamide riboside), NMN has a direct pathway to NAD+ without additional phosphorylation.