HGH Fragment 176-191 (HGH Frag)

Pen Peptide manufacturer protocol: 16–20 clicks (400–500 mcg) × 1 time daily subcutaneously, preferably before bedtime (synchronization with natural nighttime GH peak).

Start: 16 clicks (400 mcg) first 1–2 weeks; with good tolerance — increase to 20 clicks (500 mcg).

Set pen programmer to 16 or 20. Inject subcutaneously into fat folds of abdomen or thigh — where the fat you want to burn is located (localized action). Rotate injection sites. Short needle (4–6 mm), inserted at 90°. After injection — wait 10 seconds before withdrawal.

Do not combine with food for 2–3 hours before and after injection — fatty acids in blood block lipolysis effect. Therefore before bedtime is ideal time (dinner 3+ hours ago).

Course duration: full — 2 months (1 pen ~10–12 days × 6 pens). Starting — 30–45 days (3 pens).

Break between courses 4–6 weeks. Optimal 1–2 courses/year.

First noticeable results — from week 4–6.

Storage: in refrigerator at 2–8°C, do not freeze.

Recommended synergy with CJC-1295 No DAC + Ipamorelin (stimulates own GH) for complete anti-aging protocol. Before starting — consultation with DOZA specialist and glucose, lipid profile analysis.

HGH Fragment 176-191 (HGH Frag) is a synthetic peptide containing only the last 16 amino acids of human growth hormone (HGH) molecule, positions 176–191. Designed as a selective fat-burning tool that provides the key benefit of full HGH (fat loss) without its side effects: water retention, joint pain, hyperglycemia, acromegaly.

Unlike full HGH, HGH Fragment activates only lipolytic action (fat burning), NOT affecting IGF-1 levels, tissue growth, bone, or glucose metabolism. Particularly effective on abdominal and visceral fat — the most difficult type to eliminate. Clinical studies showed 10–15% reduction in fat mass over 8–12 weeks without total weight change — pure "recomposition" (fat-to-muscle replacement).

Pen Peptide produces HGH Fragment in pre-mixed pen format 5mg (200 clicks × 25 mcg), purity ≥98%, GMP-standard + stabilized MSSPT formula. Protocol: 16–20 clicks × 1 time daily before bedtime, 1 pen ~10–12 days, full course 2 months. Suitable for athletes in cutting phase, people with resistant fat after GLP-1 course, people with type 2 diabetes (no glucose impact).

Attention: HGH Fragment 176-191 is WADA-prohibited for competitive athletes (anabolic action).

HGH Fragment 176-191 is a synthetic fragment of the C-terminal of human growth hormone (amino acids 176-191 out of 191), responsible exclusively for GH lipolytic activity without anabolic or diabetogenic effects. Activates β3-adrenoreceptors on adipocyte membrane → stimulates hormone-sensitive lipase (HSL) → direct lipolysis of fat cells with triglyceride conversion to free fatty acids for β-oxidation (Ng et al., Mol Cell Endocrinol 2000). Key advantage: does NOT elevate IGF-1, does NOT affect glucose levels, does NOT suppress pituitary function — pure lipolytic agent without systemic effects of full GH. Inhibits lipogenesis (new fat cell formation). Also known as AOD-9604 (Anti-Obesity Drug 9604) — studied in Phase 2 clinical trials for obesity treatment (Heffernan et al., Obes Res 2001). Ideal for body recomposition: burns fat without affecting muscle mass.