Mounjaro in Hollywood: 8 Stars Openly Discussing Tirzepatide in 2024-2025

Just two years ago, no celebrity would admit to taking a weight loss medication. It was taboo on the level of plastic surgery. And then Oprah happened.

December 2023. Oprah Winfrey on her show publicly acknowledged taking GLP-1 agonists for the first time. And the domino effect began. Stars one by one started talking about Mounjaro openly, without shame, as a regular self-care tool.

This article isn't tabloid gossip. Only verified facts are collected here: direct quotes from interviews, media names, exact dates. Because if we're going to talk about celebrities on Mounjaro, let's be honest about it.

Why did stars suddenly start acknowledging Mounjaro in 2024-2025?

Before 2023, the topic of weight loss medications in Hollywood was closed. Dramatic weight loss was explained by "new diet," "training with a personal trainer," or simply ignored. Admitting to taking medications meant admitting weakness.

Oprah's public confession changed the rules of the game. She didn't just say she takes GLP-1, she explained why — and did it from a position of strength, not excuses. People magazine launched a series of exclusive interviews with stars about their experience. Suddenly it turned out: acknowledgment became brand positive.

Meghan Trainor in an interview directly said: "We heard more and more of our friends — and even our doctors — were on Mounjaro and Ozempic" [1]. If your friends and your doctor are taking the medication, why should you be ashamed?

Read more about how Oprah changed attitudes toward GLP-1 agonists in the article Oprah Winfrey & GLP-1 — How the TV Star Became the Face of De-stigmatization.

Tori Spelling — baby weight after 5 births (April 2024)

Beverly Hills 90210 actress Tori Spelling became one of the first stars to publicly acknowledge taking Mounjaro. This happened in April 2024 during an episode of her own podcast "misSPELLING."

Tori's story is telling. After giving birth to her fifth child in 2017, she gained weight and couldn't lose it for years. She tried different approaches, but nothing worked as she wanted.

"I tried Ozempic and it didn't work for me. So I went on Mounjaro, which did do the trick and I did lose weight" [17].

She honestly admitted that Ozempic didn't work for her, and she switched to Mounjaro. And immediately removed the stigma from this acknowledgment:

"I did Mounjaro, and everyone admits it now. It's a different time so I don't feel shamed saying that" [14].

Tori explained the application process: "So, you get a box and you get four injections. You do one a week, and that's a month's supply and you administer it to yourself. It's like an EpiPen" [12]. She described it as "foolproof."

Important nuance: Tori stopped taking Mounjaro in January 2024, having reached her desired weight. "I did go off of it because I had hit my ideal weight, and then I felt like I didn't want to get any thinner" [14]. This demonstrates a responsible approach — the medication as a tool to achieve a goal, not a lifelong dependency.

Deryl also takes the medication and supports his wife. "We did 75 Hard after [our son] Riley was born and, man, did we crush" [1], he said about their joint journey to a healthy lifestyle.

Michael McIntyre — British comedian after "obesity" diagnosis (October 2025)

Michael McIntyre is one of the most famous British comedians. In October 2025, he publicly acknowledged taking Mounjaro during a performance in London.

His story is about failures and a new beginning.

First, he tried an expensive course at the Austrian Mayr clinic. Price — about £4000. Result? "I went to this place called the Mayr Clinic and lost quite a bit of weight, which I kept off for a little while. It was a week of pain" [5]. A week on soup and crackers, depression, and the weight came back anyway.

And then doctors made a diagnosis: obesity. "The doctor told me I weighed 100kg. He told me I was 'obese'. How rude. He said, 'It's a medical term'" [5].

It was his wife Kitty who insisted he try Mounjaro. And it worked quickly.

"Have you noticed how tiny I am? I have lost weight. Don't applaud it because there is a little bit of cheating that has gone on" [4], he joked to the London audience.

The result became noticeable after just three weeks [5]. At the same time, Michael honestly admitted his weakness: he always finished the leftovers after his wife and sons Lucas and Oscar.

Rosie O'Donnell — Mounjaro for diabetes (May 2025)

Comedian and TV star Rosie O'Donnell has a special story with Mounjaro. She started taking the medication not for weight loss per se, but to treat type 2 diabetes. Weight loss was an additional effect.

In May 2025, she shared her experience with USA Today. Before that, in March, she published a TikTok video about changes in her life after moving to Ireland with daughter Clay [7].

"I know it's too expensive. It should be free to anyone who needs it, anyone who has diabetes, anyone who's suffering with all of the comorbidities of obesity. It's life-altering" [7].

This quote shows an important nuance. Rosie doesn't just praise the medication — she raises the issue of accessibility. Mounjaro is indeed expensive, and not everyone can afford it.

She also emphasized the role of lifestyle. Moving to Ireland, new habits, different rhythm — all this complemented the effect of the medication.

Pattern 1: Previous failure

Each of these stars tried other methods before Mounjaro. Michael McIntyre spent £4000 on a clinic and was left with depression. Meghan Trainor worked with a trainer and nutritionist but got stuck at 155 pounds. Tori Spelling tried Ozempic, which didn't work for her.

These aren't people looking for an easy way. These are people who exhausted other options.

Pattern 2: Medication as part of a system

None of them says: "I just inject and lie on the couch." Meghan works with a nutritionist and trainer. Eric controls his sugar. Rosie changed her lifestyle after moving.

Pattern 3: Specific trigger

All have a clear reason for starting. Childbirth (Tori, Meghan), diabetes (Rosie, Eric), medical diagnosis of "obesity" (Michael). This isn't a whim — it's a reaction to a specific life situation.

Pattern 4: Timing — after Oprah

All public acknowledgments fall in 2024-2025. Oprah opened the door in December 2023. The rest followed her.

Pattern 5: De-stigmatization instead of excuses

"I don't feel shamed" — Tori Spelling. "Shoutout to Mounjaro!" — Meghan Trainor. "It's life-altering" — Rosie O'Donnell. The tone is positive, without shame.

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